ABSTRACT
PURPOSE: This study tries to examine the effects of hand moxibustion and press pellet by applying them to male manufacturing workers with low back pain, and use them to develop nursing interventions for workers. METHODS: The data were collected from August to October, 2018, and the subjects were 60 men, processed by using SPSS/WIN 21.0 to perform homogeneity test with χ²-, t-, and hypothesis tests with repeated measures, ANOVA and Scheffé test. RESULTS: Hypothesis 1 that “the experimental group provided with hand moxibustion and hand press pellet would give lower scores for low back pain than the control group” was supported (F=78.71, p<.001). Hypothesis 2 that “the experimental group provided with hand moxibustion and hand press pellet would have a wider range of motion than the control group” was also supported (F=17.44, p<.001). Hypothesis 3 that “the experimental group provided with hand moxibustion and hand press pellet would give lower scores for depression than the control group,” again, was supported (F=16.95, p<.001). CONCLUSION: Hand moxibustion and hand press pellet are effective in relieving low back pain for male workers, in increasing the range of motion, and in decreasing depression.
Subject(s)
Humans , Male , Depression , Hand , Joints , Low Back Pain , Moxibustion , Nursing , Range of Motion, ArticularABSTRACT
PURPOSE: This study aimed to investigate variables affecting health-related quality of life of manufacturing industry workers. METHODS: We used data from 200 survey questionnaires collected from a vehicle manufacture factory located in Ulsan metropolitan area. The participants were manufacturing workers. The data were analyzed using t-test, one-way analysis of variance, and Scheffé's test to identify differences among variables. Pearson's correlation coefficient and stepwise multiple regression were used to identify variables that affected health-related quality of life. RESULTS: The findings revealed that occupational stress and quality of sleep were statistically significant variables of the physical component score with an explanatory power of 42.2%. Occupational stress, depression, and religion were statistically significant variables of the mental component score with an explanatory power of 43.3%. CONCLUSION: Continuous monitoring and appropriate intervention for occupational stress, quality of sleep, and depression are needed to improve manufacturing workers' health-related quality of life.
Subject(s)
Depression , Quality of LifeABSTRACT
PURPOSE@#This study aimed to investigate variables affecting health-related quality of life of manufacturing industry workers.@*METHODS@#We used data from 200 survey questionnaires collected from a vehicle manufacture factory located in Ulsan metropolitan area. The participants were manufacturing workers. The data were analyzed using t-test, one-way analysis of variance, and Scheffé's test to identify differences among variables. Pearson's correlation coefficient and stepwise multiple regression were used to identify variables that affected health-related quality of life.@*RESULTS@#The findings revealed that occupational stress and quality of sleep were statistically significant variables of the physical component score with an explanatory power of 42.2%. Occupational stress, depression, and religion were statistically significant variables of the mental component score with an explanatory power of 43.3%.@*CONCLUSION@#Continuous monitoring and appropriate intervention for occupational stress, quality of sleep, and depression are needed to improve manufacturing workers' health-related quality of life.
ABSTRACT
Reversible posterior leukoencephalopathy syndrome (RPLS) is a distinctive clinicoradiological entity that's characterized by headache, confusion, seizure and frequent visual disturbances. It is associated with certain neuro-radiological findings, and predominantly white matter abnormalities of the parieto-occipital lobes. RPLS has been identified mostly in patients with malignant hypertension, pre-eclampsia and renal insufficiency and in those patients who are using immunosuppressive agents or cytotoxic drugs. We report here on a case of RPLS in a patient who was undergoing chemotherapy. A 49-year-old woman presented with abrupt mental changes and visual disturbances five days after the administration of a chemotherapeutic agent. MRI showed hyper-intense signals on the magnetic resonance (MR) diffusion images in the bilateral temporal, parietal and occipital lobes. The clinical manifestations completely resolved after one week of treatment that consisted of blood pressure control, a negative intake-output balance and the best supportive care. These radiological changes and the reversible clinical manifestations were consistent with RPLS.
Subject(s)
Female , Humans , Middle Aged , Antineoplastic Combined Chemotherapy Protocols , Blood Pressure , Cisplatin , Cytarabine , Diffusion , Etoposide , Headache , Hodgkin Disease , Hypertension, Malignant , Immunosuppressive Agents , Magnetic Resonance Spectroscopy , Occipital Lobe , Posterior Leukoencephalopathy Syndrome , Pre-Eclampsia , Prednisone , Renal Insufficiency , SeizuresABSTRACT
Multicentric Castleman disease (MCD) is a rare lymphoproliferative disorder. Although MCD pathogenesis is unclear, studies have suggested that human herpesvirus 8 (HHV-8) may be associated with the disorder. Recent reports have identified MCD cases without viral infection. A 43-year-old woman presented to our hospital for fever and myalgia of 6 months' duration. The complete blood count revealed an elevated leukocyte count (15.1x10(3)/microliter) and a decreased hemoglobin level of 10.0 g/dL. The C-reactive protein level was elevated at 276.5 mg/L. Thoracic computed tomography (CT) scans revealed bilateral axillary lymphadenopathy. There was no evidence of HHV-8, human immunodeficiency virus (HIV), or Mycobacterium infection. Histologic evaluation of a lymph node biopsy from the left axilla yielded a diagnosis of MCD. Cyclophosphamide, adriamycin, vincristine, and prednisone (CHOP) were administered for a total of 4 cycles. The patient's fever and lymphadenopathy resolved after the course of chemotherapy. She has been in complete remission for 24 months at this writing. As previously reported, this case report suggests that MCD can develop without viral infection. CHOP chemotherapy may be an effective treatment option for newly diagnosed MCD patients.
Subject(s)
Adult , Female , Humans , Axilla , Biopsy , Blood Cell Count , C-Reactive Protein , Corneal Dystrophies, Hereditary , Cyclophosphamide , Doxorubicin , Fever , Castleman Disease , Hemoglobins , Herpesvirus 8, Human , HIV , Leukocyte Count , Lymph Nodes , Lymphatic Diseases , Lymphoproliferative Disorders , Mycobacterium Infections , Prednisone , Vincristine , WritingABSTRACT
PURPOSE: Bone Morphogenetic Proteins (BMPs) are members of the TGF-beta superfamily and it has been demonstrated that BMPs enhance migration, invasion and metastasis. The purpose of this study was to identify the association between the serum BMP-2 level and the progression status of gastric cancer. MATERIALS AND METHODS: Fifty-five patients with metastatic gastric cancer (metastatic disease group), six patients with early gastric cancer without lymph node metastasis (the EGC group), and ten healthy control subjects were enrolled in this study. The serum BMP-2 level was quantified by use of a commercially available ELISA kit. In EGC group patients and patients with metastatic disease, whole blood was obtained before endoscopic mucosal resection and before the commencement of a scheduled cycle of systemic chemotherapy, respectively. RESULTS: No significant difference in the mean serum BMP-2 levels was observed between the control subjects and the EGC group patients (87.95 pg/ml for the control subjects and 84.50 pg/ml for the EGC group, p=1.0). However, the metastatic disease group patients had a significantly higher level of serum BMP (179.61 pg/ml) than the control subjects and EGC group patients (87.95 pg/ml for the control subjects and 84.50 pg/ml for the EGC group, p<0.0001). Moreover, the mean serum BMP-2 level from patients with a bone metastasis was significantly higher than the mean serum BMP-2 level from patients without a bone metastasis (204.73 pg/ml versus 173.33 pg/ml, p=0.021). CONCLUSIONS: BMP-2 seems to have a role in progression to metastatic disease in gastric cancer, especially in the late stage of tumorigenesis, including invasion and metastasis. BMP-2 may facilitate bone metastasis in gastric cancer. To confirm these findings, further studies are required with tissue specimens and the use of a cancer cell line.
Subject(s)
Humans , Bone Morphogenetic Proteins , Cell Line , Cell Transformation, Neoplastic , Enzyme-Linked Immunosorbent Assay , Lymph Nodes , Morphogenesis , Neoplasm Metastasis , Stomach Neoplasms , Transforming Growth Factor betaABSTRACT
PURPOSE: The rate of second primary lung cancer development for patients with head and neck cancer (HNC) has been noted. The aim of our study was to evaluate the incidence and clinical features of suspected second primary lung cancer that developed in patients with primary HNC. MATERIALS AND METHODS: We conducted a retrospective study of 469 patients who were newly diagnosed with HNC at the Korea University Medical Center between January 2000 and December 2006. RESULTS: A total of 469 patients were included (389 men and 80 women). Eighteen patients (3.8%) had suspected second primary lung cancers. Statistically significant clinical variables for lung cancer development included the origin site for the primary HNC (oro-hypopharynx and larynx) (p=0.048), abnormal chest x-ray findings (p=0.027) and the histological HNC type (squamous cell carcinoma) (p=0.032). When the second primary lung cancers were combined with HNCs, the adjusted overall survival of patients with a second primary lung cancer was 16 months (p<0.001). CONCLUSIONS: Considering the relative risk factors for a second primary lung cancer developing in patients with HNC, advanced diagnostic tools, such as chest CT or PET CT scan, should be applied for the early detection of a second primary lung cancer.
Subject(s)
Humans , Male , Academic Medical Centers , Head , Head and Neck Neoplasms , Incidence , Korea , Lung , Lung Neoplasms , Neoplasms, Second Primary , Retrospective Studies , Risk Factors , ThoraxABSTRACT
Retinal pigment epithelial(RPE) cells play a important role in proliferative retinopathy(PVR) by the collagen production involved in the formation of PVR membrane. To evaluate the effect of L-azetidine-2-carvoxylic acid(LACA), a proline analogue, known as depressing the abnormal cell proliferation and PVR membrane formation, we examined the proliferation, collagen synthesis and migration of cultured bonine RPE cells following the addition of LACA. Differant concentrations of LACA as 1, 10, 50, 100microgram/ml was added to bovine RPE cells and cultured. The cell numbers were measured in 3, 6, 9 days, [3H]-thymidine uptake assay was done to evaluate the change of DNA synthesis, and collagen synthesis and cell migration was measured. The proliferation of PRE cells treated with LACA were significantly inhibited in a concentration and time dependant manner. [3H]-thymidine uptake and collagen synthesis of RPE migration was also significantly inhibited in proportion to the concentration. The results reveal that LACA has an inhibitory effect on cell proliferation, collagen synthesis and migration of bovine retinal pigment epithelial cells. It also suggest that the use of LACA to suppress membrane formation in the eyes with PVR can be possible.
Subject(s)
Cell Count , Cell Movement , Cell Proliferation , Collagen , DNA , Epithelial Cells , Meclizine , Membranes , Proline , Retinaldehyde , Vitreoretinopathy, ProliferativeABSTRACT
BACKGROUND: Pleural abnormality is the the most common respiratory change caused by asbestos dust inhalation and also develp other asbestos related disease after cessation of asbestos exposure. So we conducted epidemiologic study to investigate if the pleural abnormality is associated with pulmonary function change and what factors are influenced on pulmonary function impairement. METHODS: Two hundred and twenty two asbestos workers from 9 industries using asbestos in Korea were selected to measure the concentration of sectional asbestos fiber. Questionnaire, chest X-ray, PFT were also performed. All the data were analyzed by student t-test and chi-square test using SAS. Regressional analysis was performed to evaluate importent factors, for example smoking, exposure concentration, period and the existence of pleural thickening, affecting to the change of pulmonary function. RESULTS: 1) All nine industries except two, airborn asbestos fiber concentration was less than an average permissible concentration. PFT was performed on 222 workers and the percentage of male was 88.3%, their mean age was 41+/-9 years old, and the duration of asbestos exposure was 10.6+/-7.8 yrs. 2) The chest X-ray showed normal(89.19%), pulmonary Tb(inactive)(2.7%), pleral thickening (7.66%), suspected reticulonodular shadow(0.9%). 3) The mean values of height, smoking status, concentration of asbestos fiberwere not different between the subjects with pleural thickening and others, but age, cumulative pack-years, the dura-tion of asbestos exposure were higher in subjects with pleural thickening. 4) All the PFT indices were lower in the subjects with pleural thickening than in the subjects without pleural thickening. 5) Simple regression analysis showed there was a significant correlation between FEF75 which is sensitive in small airway obstruction and cumulative smoking pack-years, the duration of asbestos exposure and the concentration of asbestos fiber. 6) Multiple regression analysis showed all the pulmonary function indices were decreased as the increase of cumulative smoking pack-years and especially in the indices those are sensitive in small airway obstruction. Pleural thickening was associated with reduction in FVC,FEV1, PEFR and FEF25. CONCLUSION: The more concentration of asbestos fiber and the more duration of asbestos exposure, the greater reduction in FEF50,FEF75. Therefore PFT was important in the evaluation of early detection for small airway obstuction. Furthermore pleural thickening without asbesto-related parenchymal lung disease is associated with reduction in pulmonary function.
Subject(s)
Humans , Male , Airway Obstruction , Asbestos , Dust , Epidemiologic Studies , Inhalation , Korea , Lung Diseases , Peak Expiratory Flow Rate , Smoke , Smoking , ThoraxABSTRACT
Asbestos is widely used in the textile, asbestos cement, construction products, friction material, paper products, insulation products, chemical and plastic products because of its heat resistance, flexibility, tensile strength, and texturability. It is now generally recognized that longterm and excessive inhalation of asbestos dust causes asbestosis, lung cancer, malignant mesothelioma and malignancies in other organs such as cancer of gastrointestinal tract, leukemia, lymphoma. Although eighty thousand tons of asbestos has been annually consumed since 1979 in korea, it has not been reported asbestos and lung cancer by asbestos dust so far, while a case of mesothelioma was officially diagnosis as a occupational disease at 1993. We experienced firstly a case of asbestosis and lung cancer caused simultanously by occupational asbestos exposure 11 years, which was confirmed by chest x-ray, pulmonary function test, chest CT and HRCT, bronchoalveolar lavage, and gallium scan. And so We present a case of asbestosis, pleural effusion and lung cancer with a review literature.